The Effectiveness of Process-Based Therapy on Worry, Intolerance of Uncertainty, and Cognitive Flexibility in Individuals with Generalized Anxiety
Keywords:
Process-Based Therapy, Worry, Intolerance of Uncertainty, Cognitive Flexibility, Generalized AnxietyAbstract
Objective: This study aimed to determine the effectiveness of process-based therapy in reducing worry and intolerance of uncertainty and increasing cognitive flexibility among individuals with generalized anxiety.
Methods and Materials: The present study employed a quasi-experimental pretest–posttest design with a control group. The statistical population consisted of adults with clinical symptoms of generalized anxiety. Forty participants were selected through convenience sampling and assigned to an experimental group and a control group, with 20 participants in each group. The experimental group received process-based therapy in ten weekly 90-minute sessions, whereas the control group received no psychological intervention during the study period. Data were collected using the Penn State Worry Questionnaire, the Intolerance of Uncertainty Scale, and the Cognitive Flexibility Inventory. The collected data were analyzed using multivariate and univariate analysis of covariance in SPSS-27.
Findings: The results of multivariate analysis of covariance showed that, after controlling for pretest scores, there was a significant difference between the experimental and control groups in the combined dependent variables. Wilks’ lambda was 0.571, F was 8.27, and the significance level was 0.001. The effect size was 0.429, indicating that 42.9% of the variance in the combined research variables was explained by the intervention. The results of univariate analysis of covariance also indicated that process-based therapy had a significant effect on reducing intolerance of uncertainty, F=16.09, p=0.001, reducing worry, F=25.00, p=0.001, and increasing cognitive flexibility, F=4.36, p=0.044.
Conclusion: The findings suggest that process-based therapy, by targeting the underlying and maintaining processes of generalized anxiety, including excessive worry, need for certainty, safety-seeking behaviors, control strategies, and cognitive inflexibility, can be considered an effective intervention for reducing worry and intolerance of uncertainty and improving cognitive flexibility in individuals with generalized anxiety.
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References
Asfour, N. M., Helal, S. A., Almahdi, A. H., & Basha, A. M. (2024). Cognitive deficits in generalized anxiety disorder: Impairments in attention, executive functioning, and cognitive flexibility among young adults. Journal of Angiotherapy, 8(11), 1-7. https://doi.org/10.25163/angiotherapy.81110029
Bachmann, S. E. (2020). The relationship between worries and safety-seeking behaviour in Generalized Anxiety Disorder
Borsboom, D. (2017). A network theory of mental disorders. World Psychiatry, 16(1), 5-13. https://doi.org/10.1002/wps.20375
Brewer, J. A., Roy, A., Deluty, A., Liu, T., & Hoge, E. A. (2020). Can mindfulness mechanistically target worry to improve sleep disturbances? Theory and study protocol for app-based anxiety program. Health Psychology, 39(9), 776. https://doi.org/10.1037/hea0000874
Burger, J., Isvoranu, A. M., Lunansky, G., Haslbeck, J. M. B., Epskamp, S., Hoekstra, R. H. A., Fried, E. I., Borsboom, D., & Blanken, T. F. (2020). Reporting standards for psychological network analyses in cross-sectional data. Psychological Methods, 28(4), 806-824. https://doi.org/10.1037/met0000471
Citkowska-Kisielewska, A., Rutkowski, K., Sobanski, J. A., Dembinska, E., & Mielimaka, M. (2019). Anxiety symptoms in obsessive-compulsive disorder and generalized anxiety disorder. Psychiatria Polska, 53(4), 845-864. https://doi.org/10.12740/PP/105378
Dugas, M. J., Sexton, K. A., Hebert, E. A., Bouchard, S., Gouin, J. P., & Shafran, R. (2022). Behavioral experiments for intolerance of uncertainty: A randomized clinical trial for adults with generalized anxiety disorder. Behavior therapy, 53(6), 1147-1160. https://doi.org/10.1016/j.beth.2022.05.003
Gerdan, G. (2025). Exploring the role of contrast avoidance, worry, and rumination in the relationship between intolerance of uncertainty, generalized anxiety disorder, and panic disorder symptoms in a clinical sample. Current Psychology, 44(7), 6362-6375. https://doi.org/10.1007/s12144-025-07641-1
Goodwin, G. M. (2015). The overlap between anxiety, depression, and obsessive-compulsive disorder. Dialogues in clinical neuroscience, 17(3), 249-260. https://doi.org/10.31887/DCNS.2015.17.3/ggoodwin
Hayes, S. C., Ciarrochi, J., Hofmann, S. G., Chin, F., & Sahdra, B. (2022). Evolving an idionomic approach to processes of change: Towards a unified personalized science of human improvement. Behaviour Research and Therapy, 156, 104155. https://doi.org/10.1016/j.brat.2022.104155
Hayes, S. C., Hofmann, S. G., & Wilson, D. S. (2020). Clinical psychology is an applied evolutionary science. Clinical psychology review, 81, 101892. https://doi.org/10.1016/j.cpr.2020.101892
Hofmann, S. G., & Hayes, S. C. (2019). The future of intervention science: Process-based therapy. Clinical Psychological Science, 7, 37-50. https://doi.org/10.1177/2167702618772296
Hofmann, S. G., Hayes, S. C., & Lorscheid, D. N. (2021). Learning Process-Based Therapy: A Skills Training Manual for Targeting the Core Processes of Psychological Change in Clinical Practice. New Harbinger.
Laposa, J. M., Katz, D. E., Lisi, D. M., Hawley, L. L., Quigley, L., & Rector, N. A. (2022). Longitudinal changes in intolerance of uncertainty and worry severity during CBT for generalized anxiety disorder. Journal of anxiety disorders, 91, 102623. https://doi.org/10.1016/j.janxdis.2022.102623
Lim, C. Y., & Mankiewicz, P. D. (2024). Cognitive flexibility as a mediator in the relationship between generalized anxiety and paranoid ideation: The role of perceived control. Journal of Cognitive Psychotherapy, 38(4). https://doi.org/10.1891/JCP-2023-0034
Ma, R., Zhang, Q., Zhang, C., & Xu, W. (2024). Longitudinal associations between family functioning and generalized anxiety among adolescents: The mediating role of self-identity and cognitive flexibility. BMC psychology, 12(1), 399. https://doi.org/10.1186/s40359-024-01908-1
McKnight-Eily, L. R. (2021). Racial and ethnic disparities in the prevalence of stress and worry, mental health conditions, and increased substance use among adults during the COVID-19 pandemic-United States, April and May 2020. MMWR. Morbidity and mortality weekly report, 70. https://doi.org/10.15585/mmwr.mm7005a3
Mishra, A. K., Varma, A. R., & Varma, A. (2023). A comprehensive review of the generalized anxiety disorder. Cureus, 15(9). https://doi.org/10.7759/cureus.46115
Munir, S., & Takov, V. (2022). Generalized Anxiety Disorder. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK441870
Newman, M. G., Basterfield, C., Erickson, T. M., Caulley, E., Przeworski, A., & Llera, S. J. (2022). Psychotherapeutic treatments for generalized anxiety disorder: Cognitive and behavioral therapies, enhancement strategies, and emerging efforts. Expert Review of Neurotherapeutics, 22(9), 751-770. https://doi.org/10.1080/14737175.2022.2125800
Newman, M. G., Llera, S. J., Erickson, T. M., Przeworski, A., & Castonguay, L. G. (2013). Worry and generalized anxiety disorder: A review and theoretical synthesis of evidence on nature, etiology, mechanisms, and treatment. Annual Review of Clinical Psychology, 9(1), 275-297. https://doi.org/10.1146/annurev-clinpsy-050212-185544
Ong, C. W., Hofmann, S. G., Ciarrochi, J., Menzies, R. G., & Hayes, S. C. (2025). Introduction to the special issue on process-based therapy. Journal of Contextual Behavioral Science, 35, 100874. https://doi.org/10.1016/j.jcbs.2025.100874
Rajagopal, M. (2025). Generalized Anxiety Disorder: Symptoms and causes. Tamil Psychiatry Journal, 1(2), 10-11.
Riley, J. A., Wilson, E. J., Norton, A. R., & Abbott, M. J. (2026). Exploring the role of early maladaptive schemas and intolerance of uncertainty in generalized anxiety disorder. British Journal of Clinical Psychology, 65(1), 199-217. https://doi.org/10.1111/bjc.70012
Saberi, J., Bahrami Pour, M., Ghamrani, A., & Yarmohammadian, A. (2014). The effectiveness of positive parenting group program on reducing parent stress in mothers with children with autism disorder. Knowledge and research in applied psychology, 15(2), 69-77.
Soltani, E., Shareh, H., Bahrainian, S. A., & Farmani, A. (2013). The mediating role of cognitive flexibility in correlation of coping styles and resilience with depression. Pajoohandeh Journal, 18(2), 88-96.
Stein, M. B., & Sareen, J. (2015). Generalized anxiety disorder. New England Journal of Medicine, 373(21), 2059-2068. https://doi.org/10.1056/NEJMcp1502514
Thompson, C. J., & Martin-Wagar, C. A. (2025). Cognitive flexibility and emotion regulation in eating disorder patients with comorbid generalized anxiety and posttraumatic stress symptoms. Eating Disorders, 33(5), 666-680. https://doi.org/10.1080/10640266.2024.2405290
Timulak, L., Keogh, D., Chigwedere, C., Wilson, C., Ward, F., Hevey, D., & Mahon, S. (2022). A comparison of emotion-focused therapy and cognitive-behavioral therapy in the treatment of generalized anxiety disorder: Results of a feasibility randomized controlled trial. Psychotherapy, 59(1), 84. https://doi.org/10.1037/pst0000427
Wilson, E. J., Abbott, M. J., & Norton, A. R. (2023). The impact of psychological treatment on intolerance of uncertainty in generalized anxiety disorder: A systematic review and meta-analysis. Journal of anxiety disorders, 97, 102729. https://doi.org/10.1016/j.janxdis.2023.102729
Wilson, E. J., Abbott, M. J., Norton, A. R., Berle, D., & Rapee, R. M. (2026). Exploring pathways from intolerance of uncertainty to worry in adults with generalised anxiety disorder. Cognitive behaviour therapy, 55(1), 96-116. https://doi.org/10.1080/16506073.2025.2478246
Yazici Celebi, G., Gungor, S., & Kaya, F. (2025). The role of cognitive flexibility and psychological well-being in the effect of mindfulness on problematic internet use. Scientific reports, 15(1), 31373. https://doi.org/10.1038/s41598-025-16858-w
Yook, K., Kim, K. H., Suh, S. Y., & Lee, K. S. (2010). Intolerance of uncertainty, worry, and rumination in major depressive disorder and generalized anxiety disorder. Journal of anxiety disorders, 24(6), 623-628. https://doi.org/10.1016/j.janxdis.2010.04.003
Zinbarg, R. E., Anand, D., Lee, J. K., Kendall, A. D., Nunez, M., & Blaney, P. H. (2015). Generalized anxiety disorder, panic disorder, social anxiety disorder, and specific phobias. In Oxford Textbook of Psychopathology (pp. 133-162).
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